IPR023019

Domain • IPR023019

Synonyms

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Linked items?Related concepts, ordered by their global importance in the network.

phosphoribosyl-AMP cyclohydrolase activity    phosphoribosyl-ATP pyrophosphatase activity   

Related concepts

# Concept name Type Relation Support Score
1 phosphoribosyl-ATP pyrophosphatase activity Function Known Explain 916.45110
2 phosphoribosyl-AMP cyclohydrolase activity Function Known Explain 708.31095
3 Histidine biosynthesis trifunctional-protein Domain Inferred Explain 161.18212
4 Phosphoribosyl-ATP pyrophosphohydrolase Domain Inferred Explain 128.49731
5 Phosphoribosyl-AMP cyclohydrolase Domain Inferred Explain 36.47318
6 pyrophosphatase activity Function Inferred Explain 35.88541
7 histidine biosynthetic process Function Inferred Explain 24.59809
8 cyclohydrolase activity Function Inferred Explain 14.36942
9 Histidinol dehydrogenase, prokaryotic-type Domain Inferred Explain 3.67781
10 Histidinol dehydrogenase, conserved site Domain Inferred Explain 3.39503
11 histidinol dehydrogenase activity Function Inferred Explain 2.83668
12 IPR022695 Domain Inferred Explain 1.16908
13 methenyltetrahydromethanopterin cyclohydrolase activity Function Inferred Explain 0.44564
14 IPR020621 Domain Inferred Explain 0.41263
15 Histidine biosynthesis HisG: ATP phosphoribosyltransferase Domain Inferred Explain 0.38518
16 GTP cyclohydrolase activity Function Inferred Explain 0.32988
17 ATP phosphoribosyltransferase, catalytic region Domain Inferred Explain 0.31244
18 Histidine biosynthesis Domain Inferred Explain 0.29951
19 Imidazoleglycerol-phosphate dehydratase, conserved site Domain Inferred Explain 0.29617
20 Imidazoleglycerol-phosphate dehydratase Domain Inferred Explain 0.28626
21 Histidine biosynthesis HisG, C-terminal Domain Inferred Explain 0.28405
22 methenyltetrahydrofolate cyclohydrolase activity Function Inferred Explain 0.26608
23 Histidine biosynthesis bifunctional protein hisB Domain Inferred Explain 0.26084
24 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic Domain Inferred Explain 0.24364
25 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Domain Inferred Explain 0.19781
26 CDP-diacylglycerol diphosphatase activity Function Inferred Explain 0.19503
27 IMP cyclohydrolase activity Function Inferred Explain 0.18834
28 Histidine biosynthesis, HisF Domain Inferred Explain 0.17856
29 hydrogen-translocating pyrophosphatase activity Function Inferred Explain 0.17494
30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Function Inferred Explain 0.16774
31 Bifunctional HisA/TrpF Domain Inferred Explain 0.16422
32 ATP phosphoribosyltransferase activity Function Inferred Explain 0.16211
33 Aldehyde/histidinol dehydrogenase Domain Inferred Explain 0.16175
34 Histidinol-phosphatase Domain Inferred Explain 0.16154
35 undecaprenyl-diphosphatase activity Function Inferred Explain 0.16136
36 exopolyphosphatase activity Function Inferred Explain 0.16084
37 CDP-glycerol diphosphatase activity Function Inferred Explain 0.15899
38 dolichyldiphosphatase activity Function Inferred Explain 0.15851
39 UDP-sugar diphosphatase activity Function Inferred Explain 0.15782
40 endopolyphosphatase activity Function Inferred Explain 0.15547
41 Apyrase Domain Inferred Explain 0.15027
42 DHHA2 Domain Inferred Explain 0.14856
43 Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H Domain Inferred Explain 0.14497
44 Imidazole glycerol phosphate synthase, subunit H Domain Inferred Explain 0.14352
45 Methenyltetrahydromethanopterin cyclohydrolase Domain Inferred Explain 0.14232
46 ATP phosphoribosyltransferase, conserved site Domain Inferred Explain 0.14177
47 Histidinol phosphate phosphatase, HisJ Domain Inferred Explain 0.13323
48 UDP-2,3-diacylglucosamine hydrolase Domain Inferred Explain 0.12724
49 ADP-sugar diphosphatase activity Function Inferred Explain 0.12695
50 inorganic diphosphatase activity Function Inferred Explain 0.12372
51 diphosphoinositol polyphosphate phosphohydrolase activity Function Inferred Explain 0.11761
52 nucleoside-diphosphatase activity Function Inferred Explain 0.11658
53 nucleotide pyrophosphatase activity Function Inferred Explain 0.11197
54 Histidinol-phosphate aminotransferase Domain Inferred Explain 0.10850
55 IPR023016 Domain Inferred Explain 0.10514
56 imidazoleglycerol-phosphate dehydratase activity Function Inferred Explain 0.10377
57 histidine family amino acid biosynthetic process Function Inferred Explain 0.10226
58 nucleoside-triphosphate diphosphatase activity Function Inferred Explain 0.09986
59 Histidyl-tRNA synthetase, class IIa, putative Domain Inferred Explain 0.09986
60 PRUNE2 gene Gene Inferred Explain 0.07987
61 Imidazole glycerol phosphate synthase HisHF Domain Inferred Explain 0.07572
62 MTHFD2L gene Gene Inferred Explain 0.06978
63 Nitrogen regulatory PII-like, alpha/beta Domain Inferred Explain 0.06832
64 GTP cyclohydrolase II activity Function Inferred Explain 0.06646
65 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal Domain Inferred Explain 0.06183
66 histidinol-phosphatase activity Function Inferred Explain 0.05676
67 Bacitracin resistance protein BacA Domain Inferred Explain 0.05472
68 Inorganic H+ pyrophosphatase Domain Inferred Explain 0.05281
69 IPR022371 Domain Inferred Explain 0.05248
70 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Function Inferred Explain 0.05096
71 CDP-diacylglycerol pyrophosphatase, proteobacterial Domain Inferred Explain 0.04943
72 C17orf48 gene Gene Inferred Explain 0.04902
73 Endopolyphosphatase, Ppn1p-related Domain Inferred Explain 0.04810
74 CDP-diacylglycerol pyrophosphatase, bacterial Domain Inferred Explain 0.04673
75 GTP cyclohydrolase III Domain Inferred Explain 0.04236
76 Polynucleotide kinase 3 phosphatase, central region Domain Inferred Explain 0.04111
77 Oxidation-Reduction Function Inferred Explain 0.04002
78 P-P-bond-hydrolysis-driven transmembrane transporter activity Function Inferred Explain 0.03293
79 NUDT14 gene Gene Inferred Explain 0.03157
80 MTHFD1 gene Gene Inferred Explain 0.02850
81 GTP cyclohydrolase I activity Function Inferred Explain 0.02788
82 Histidine Metabolism Pathway Function Inferred Explain 0.02700
83 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Function Inferred Explain 0.02419
84 GTP cyclohydrolase II Domain Inferred Explain 0.02209
85 DOLPP1 gene Gene Inferred Explain 0.02183
86 heterocycle biosynthetic process Function Inferred Explain 0.02165
87 Glutamine amidotransferase class-I, C-terminal Domain Inferred Explain 0.01962
88 CANT1 gene Gene Inferred Explain 0.01958
89 Glycosyl amidation-associated protein, WbuZ Domain Inferred Explain 0.01954
90 imidazoleglycerol-phosphate synthase activity Function Inferred Explain 0.01824
91 PHP, C-terminal Domain Inferred Explain 0.01764
92 histidine family amino acid metabolic process Function Inferred Explain 0.01739
93 ADP-ribose diphosphatase activity Function Inferred Explain 0.01729
94 nucleoside triphosphatase activity Function Inferred Explain 0.01588
95 Ribulose-phosphate binding barrel Domain Inferred Explain 0.01553
96 Nitrogen regulatory protein P-II, urydylation site Domain Inferred Explain 0.01426
97 Nitrogen regulatory protein PII, conserved site Domain Inferred Explain 0.01426
98 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function Inferred Explain 0.01344
99 histidinol-phosphate aminotransferase activity Function Inferred Explain 0.01288
100 Histidinol-phosphate phosphatase Domain Inferred Explain 0.01272