Histidine biosynthesis trifunctional-protein

Domain • IPR016298

Synonyms

There are no synonyms of this concept in our database.

Linked items?Related concepts, ordered by their global importance in the network.

Oxidation-Reduction    histidine biosynthetic process    Histidinol dehydrogenase, prokaryotic-type    Histidinol dehydrogenase, conserved site    histidinol dehydrogenase activity    phosphoribosyl-AMP cyclohydrolase activity    phosphoribosyl-ATP pyrophosphatase activity    Phosphoribosyl-AMP cyclohydrolase   

Related concepts

# Concept name Type Relation Support Score
1 phosphoribosyl-AMP cyclohydrolase activity Function Known Explain 95.55042
2 Phosphoribosyl-AMP cyclohydrolase Domain Known Explain 90.47343
3 phosphoribosyl-ATP pyrophosphatase activity Function Known Explain 73.94924
4 Histidinol dehydrogenase, prokaryotic-type Domain Known Explain 73.23336
5 Histidinol dehydrogenase, conserved site Domain Known Explain 67.65624
6 histidinol dehydrogenase activity Function Known Explain 65.86852
7 histidine biosynthetic process Function Known Explain 49.00248
8 IPR023019 Domain Inferred Explain 32.09032
9 IPR022695 Domain Inferred Explain 16.59673
10 Phosphoribosyl-ATP pyrophosphohydrolase Domain Inferred Explain 12.32539
11 cyclohydrolase activity Function Inferred Explain 5.94821
12 Aldehyde/histidinol dehydrogenase Domain Inferred Explain 2.75021
13 pyrophosphatase activity Function Inferred Explain 2.40171
14 IPR020621 Domain Inferred Explain 1.09658
15 Histidine biosynthesis HisG: ATP phosphoribosyltransferase Domain Inferred Explain 1.03976
16 Imidazoleglycerol-phosphate dehydratase, conserved site Domain Inferred Explain 0.87813
17 Histidine biosynthesis Domain Inferred Explain 0.86632
18 ATP phosphoribosyltransferase, catalytic region Domain Inferred Explain 0.86129
19 Imidazoleglycerol-phosphate dehydratase Domain Inferred Explain 0.85018
20 Histidine biosynthesis HisG, C-terminal Domain Inferred Explain 0.79057
21 Histidine biosynthesis bifunctional protein hisB Domain Inferred Explain 0.78481
22 Oxidation-Reduction Function Known Explain 0.77000
23 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic Domain Inferred Explain 0.72354
24 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Domain Inferred Explain 0.57517
25 Histidine biosynthesis, HisF Domain Inferred Explain 0.53442
26 Histidinol-phosphatase Domain Inferred Explain 0.47036
27 Bifunctional HisA/TrpF Domain Inferred Explain 0.46843
28 Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H Domain Inferred Explain 0.46387
29 Imidazole glycerol phosphate synthase, subunit H Domain Inferred Explain 0.44668
30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Function Inferred Explain 0.43868
31 Histidinol phosphate phosphatase, HisJ Domain Inferred Explain 0.41718
32 ATP phosphoribosyltransferase activity Function Inferred Explain 0.39702
33 Histidinol-phosphate aminotransferase Domain Inferred Explain 0.34837
34 ATP phosphoribosyltransferase, conserved site Domain Inferred Explain 0.34560
35 histidine family amino acid biosynthetic process Function Inferred Explain 0.33651
36 Histidyl-tRNA synthetase, class IIa, putative Domain Inferred Explain 0.33247
37 imidazoleglycerol-phosphate dehydratase activity Function Inferred Explain 0.28209
38 IPR023016 Domain Inferred Explain 0.27220
39 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function Inferred Explain 0.25163
40 Imidazole glycerol phosphate synthase HisHF Domain Inferred Explain 0.20254
41 MTHFD2L gene Gene Inferred Explain 0.17825
42 histidinol-phosphatase activity Function Inferred Explain 0.15831
43 Nitrogen regulatory PII-like, alpha/beta Domain Inferred Explain 0.15348
44 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal Domain Inferred Explain 0.13886
45 methenyltetrahydromethanopterin cyclohydrolase activity Function Inferred Explain 0.13519
46 NAD or NADH binding Function Inferred Explain 0.12178
47 Polynucleotide kinase 3 phosphatase, central region Domain Inferred Explain 0.10852
48 methenyltetrahydrofolate cyclohydrolase activity Function Inferred Explain 0.10719
49 GTP cyclohydrolase activity Function Inferred Explain 0.09599
50 Histidine Metabolism Pathway Function Inferred Explain 0.08671
51 MTHFD1 gene Gene Inferred Explain 0.07223
52 heterocycle biosynthetic process Function Inferred Explain 0.06609
53 IMP cyclohydrolase activity Function Inferred Explain 0.05893
54 Glutamine amidotransferase class-I, C-terminal Domain Inferred Explain 0.05442
55 histidine family amino acid metabolic process Function Inferred Explain 0.05145
56 Glycosyl amidation-associated protein, WbuZ Domain Inferred Explain 0.05100
57 imidazoleglycerol-phosphate synthase activity Function Inferred Explain 0.04906
58 PHP, C-terminal Domain Inferred Explain 0.04870
59 Methenyltetrahydromethanopterin cyclohydrolase Domain Inferred Explain 0.04012
60 histidinol-phosphate aminotransferase activity Function Inferred Explain 0.03791
61 Ribulose-phosphate binding barrel Domain Inferred Explain 0.03579
62 Histidinol-phosphate phosphatase Domain Inferred Explain 0.03142
63 Nitrogen regulatory protein P-II, urydylation site Domain Inferred Explain 0.02804
64 Nitrogen regulatory protein PII, conserved site Domain Inferred Explain 0.02804
65 pentosyltransferase activity Function Inferred Explain 0.02556
66 phosphoribosylanthranilate isomerase activity Function Inferred Explain 0.02523
67 Aminotransferase, class-II, pyridoxal-phosphate binding site Domain Inferred Explain 0.02521
68 Gamma-glutamyl phosphate reductase GPR, conserved site Domain Inferred Explain 0.02330
69 Ribosomal protein S5 domain 2-type fold Domain Inferred Explain 0.02315
70 Aldehyde dehydrogenase, C-terminal Domain Inferred Explain 0.02148
71 Aldehyde dehydrogenase Domain Inferred Explain 0.02079
72 Aldehyde dehydrogenase, N-terminal Domain Inferred Explain 0.01837
73 Nitrogen regulatory protein PII Domain Inferred Explain 0.01769
74 Acyl-CoA reductase Domain Inferred Explain 0.01760
75 Succinylglutamic semialdehyde dehydrogenase Domain Inferred Explain 0.01705
76 GTP cyclohydrolase II activity Function Inferred Explain 0.01670
77 Aldehyde dehydrogenase, conserved site Domain Inferred Explain 0.01609
78 Histidyl-tRNA synthetase, class IIa Domain Inferred Explain 0.01513
79 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Function Inferred Explain 0.01505
80 intramolecular oxidoreductase activity, interconverting aldoses and ketoses Function Inferred Explain 0.01384
81 oxo-acid-lyase activity Function Inferred Explain 0.01331
82 oxidoreductase activity Function Inferred Explain 0.01247
83 Aminoacyl-tRNA synthetase, class II (G, H, P and S), conserved region Domain Inferred Explain 0.01167
84 GTP cyclohydrolase III Domain Inferred Explain 0.01154
85 Amino Acid Biosynthesis Function Inferred Explain 0.01147
86 tryptophan biosynthetic process Function Inferred Explain 0.01017
87 CDP-diacylglycerol diphosphatase activity Function Inferred Explain 0.00957
88 Divalent ion tolerance protein, CutA1 Domain Inferred Explain 0.00947
89 Cytoplasm Component Inferred Explain 0.00871
90 hydrogen-translocating pyrophosphatase activity Function Inferred Explain 0.00869
91 dolichyldiphosphatase activity Function Inferred Explain 0.00833
92 UDP-sugar diphosphatase activity Function Inferred Explain 0.00828
93 CDP-glycerol diphosphatase activity Function Inferred Explain 0.00823
94 undecaprenyl-diphosphatase activity Function Inferred Explain 0.00822
95 exopolyphosphatase activity Function Inferred Explain 0.00821
96 CUTA gene Gene Inferred Explain 0.00810
97 endopolyphosphatase activity Function Inferred Explain 0.00798
98 Apyrase Domain Inferred Explain 0.00791
99 DHHA2 Domain Inferred Explain 0.00787
100 GTP cyclohydrolase I activity Function Inferred Explain 0.00724