|
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
Regulator of G protein signalling superfamily
|
Domain
|
Known
|
Explain
|
7.42435
|
|
2
|
RGS8 gene
|
Gene
|
Known
|
Explain
|
3.36978
|
|
3
|
RGS21 gene
|
Gene
|
Known
|
Explain
|
3.36978
|
|
4
|
RGS22 gene
|
Gene
|
Known
|
Explain
|
3.17344
|
|
5
|
RGS17 gene
|
Gene
|
Known
|
Explain
|
3.00125
|
|
6
|
SNX25 gene
|
Gene
|
Known
|
Explain
|
2.52653
|
|
7
|
SNX14 gene
|
Gene
|
Known
|
Explain
|
2.46925
|
|
8
|
RGS18 gene
|
Gene
|
Known
|
Explain
|
2.32226
|
|
9
|
RGS11 gene
|
Gene
|
Known
|
Explain
|
1.98085
|
|
10
|
SNX13 gene
|
Gene
|
Known
|
Explain
|
1.96741
|
|
11
|
RGS14 gene
|
Gene
|
Known
|
Explain
|
1.88698
|
|
12
|
RGS13 gene
|
Gene
|
Known
|
Explain
|
1.85174
|
|
13
|
RGS6 gene
|
Gene
|
Known
|
Explain
|
1.80750
|
|
14
|
RGS5 gene
|
Gene
|
Known
|
Explain
|
1.77609
|
|
15
|
GRK4 gene
|
Gene
|
Known
|
Explain
|
1.56062
|
|
16
|
RGS10 gene
|
Gene
|
Known
|
Explain
|
1.44313
|
|
17
|
GRK7 gene
|
Gene
|
Known
|
Explain
|
1.39517
|
|
18
|
RGS7 gene
|
Gene
|
Known
|
Explain
|
1.38632
|
|
19
|
RGS9 gene
|
Gene
|
Known
|
Explain
|
1.28985
|
|
20
|
RGS16 gene
|
Gene
|
Known
|
Explain
|
1.25718
|
|
21
|
RGS1 gene
|
Gene
|
Known
|
Explain
|
1.24185
|
|
22
|
RGS4 gene
|
Gene
|
Known
|
Explain
|
1.22743
|
|
23
|
RGS19 gene
|
Gene
|
Known
|
Explain
|
1.21765
|
|
24
|
RGS12 gene
|
Gene
|
Known
|
Explain
|
1.17734
|
|
25
|
RGS20 gene
|
Gene
|
Known
|
Explain
|
1.12862
|
|
26
|
RGS3 gene
|
Gene
|
Known
|
Explain
|
1.05267
|
|
27
|
GRK6 gene
|
Gene
|
Known
|
Explain
|
1.05185
|
|
28
|
signal transducer activity
|
Function
|
Known
|
Explain
|
0.92939
|
|
29
|
negative regulation of signal transduction
|
Function
|
Inferred
|
Explain
|
0.82468
|
|
30
|
GRK5 gene
|
Gene
|
Known
|
Explain
|
0.76700
|
|
31
|
RGS2 gene
|
Gene
|
Known
|
Explain
|
0.65493
|
|
32
|
GTPase activator activity
|
Function
|
Inferred
|
Explain
|
0.39869
|
|
33
|
regulation of G-protein coupled receptor protein signaling pathway
|
Function
|
Inferred
|
Explain
|
0.29284
|
|
34
|
Sorting nexin, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.28724
|
|
35
|
Phox-associated domain
|
Domain
|
Inferred
|
Explain
|
0.27605
|
|
36
|
G-protein, gamma-like subunit
|
Domain
|
Inferred
|
Explain
|
0.15272
|
|
37
|
GNAI3 gene
|
Gene
|
Inferred
|
Explain
|
0.14221
|
|
38
|
GNAI1 gene
|
Gene
|
Inferred
|
Explain
|
0.11943
|
|
39
|
GNAO1 gene
|
Gene
|
Inferred
|
Explain
|
0.09929
|
|
40
|
heterotrimeric G-protein complex location
|
Component
|
Inferred
|
Explain
|
0.08669
|
|
41
|
OSTM1 gene
|
Gene
|
Inferred
|
Explain
|
0.08428
|
|
42
|
Pleckstrin/G-protein, interacting region
|
Domain
|
Inferred
|
Explain
|
0.07878
|
|
43
|
Phox-like
|
Domain
|
Inferred
|
Explain
|
0.06745
|
|
44
|
GNB5 gene
|
Gene
|
Inferred
|
Explain
|
0.06645
|
|
45
|
GNAI2 gene
|
Gene
|
Inferred
|
Explain
|
0.06235
|
|
46
|
GPCR kinase
|
Domain
|
Inferred
|
Explain
|
0.06181
|
|
47
|
GNAQ gene
|
Gene
|
Inferred
|
Explain
|
0.06072
|
|
48
|
G-protein coupled receptor kinase activity
|
Function
|
Inferred
|
Explain
|
0.06049
|
|
49
|
phosphoinositide binding
|
Function
|
Inferred
|
Explain
|
0.05355
|
|
50
|
PX-associated, sorting nexin 13
|
Domain
|
Inferred
|
Explain
|
0.04755
|
|
51
|
Cell membrane
|
Component
|
Inferred
|
Explain
|
0.03892
|
|
52
|
GNAZ gene
|
Gene
|
Inferred
|
Explain
|
0.03247
|
|
53
|
GoLoco motif
|
Domain
|
Inferred
|
Explain
|
0.03240
|
|
54
|
SNX19 gene
|
Gene
|
Inferred
|
Explain
|
0.03166
|
|
55
|
Cytoplasm
|
Component
|
Inferred
|
Explain
|
0.02978
|
|
56
|
Raf-like Ras-binding
|
Domain
|
Inferred
|
Explain
|
0.02919
|
|
57
|
positive regulation of GTPase activity
|
Function
|
Inferred
|
Explain
|
0.02792
|
|
58
|
AGC-kinase, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.02697
|
|
59
|
Cell Communication
|
Function
|
Inferred
|
Explain
|
0.02694
|
|
60
|
GDE1 gene
|
Gene
|
Inferred
|
Explain
|
0.02353
|
|
61
|
Blocadren
|
Compound
|
Inferred
|
Explain
|
0.01674
|
|
62
|
RGS9BP gene
|
Gene
|
Inferred
|
Explain
|
0.01665
|
|
63
|
KEGG:hsa04744
|
|
Inferred
|
Explain
|
0.01184
|
|
64
|
PERRS Gene
|
Disease
|
Inferred
|
Explain
|
0.01146
|
|
65
|
receptor signaling protein activity
|
Function
|
Inferred
|
Explain
|
0.01134
|
|
66
|
STMN2 gene
|
Gene
|
Inferred
|
Explain
|
0.01059
|
|
67
|
Phosphorhodopsin
|
Compound
|
Inferred
|
Explain
|
0.01028
|
|
68
|
Chemokine signaling pathway - Homo sapiens (human)
|
Pathway
|
Inferred
|
Explain
|
0.00920
|
|
69
|
GNAT1 gene
|
Gene
|
Inferred
|
Explain
|
0.00865
|
|
70
|
negative regulation of G-protein coupled receptor protein signaling pathway
|
Function
|
Inferred
|
Explain
|
0.00798
|
|
71
|
Regulator of G protein signalling-like fold
|
Domain
|
Inferred
|
Explain
|
0.00791
|
|
72
|
Winged helix repressor DNA-binding
|
Domain
|
Inferred
|
Explain
|
0.00755
|
|
73
|
Psychoses, Drug
|
Disease
|
Inferred
|
Explain
|
0.00726
|
|
74
|
nickel sulfate
|
Compound
|
Inferred
|
Explain
|
0.00707
|
|
75
|
CALM1 gene
|
Gene
|
Inferred
|
Explain
|
0.00674
|
|
76
|
BDKRB2 gene
|
Gene
|
Inferred
|
Explain
|
0.00664
|
|
77
|
Serine/threonine protein kinase
|
Domain
|
Inferred
|
Explain
|
0.00642
|
|
78
|
protein transport
|
Function
|
Inferred
|
Explain
|
0.00637
|
|
79
|
RCVRN gene
|
Gene
|
Inferred
|
Explain
|
0.00627
|
|
80
|
Benzo(a)pyrene
|
Compound
|
Inferred
|
Explain
|
0.00607
|
|
81
|
Endocytosis - Homo sapiens (human)
|
Pathway
|
Inferred
|
Explain
|
0.00607
|
|
82
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
|
Compound
|
Inferred
|
Explain
|
0.00593
|
|
83
|
FSHR gene
|
Gene
|
Inferred
|
Explain
|
0.00562
|
|
84
|
Serine/threonine protein kinase-related
|
Domain
|
Inferred
|
Explain
|
0.00553
|
|
85
|
Rhodopsin
|
Compound
|
Inferred
|
Explain
|
0.00547
|
|
86
|
Essential Hypertension
|
Disease
|
Inferred
|
Explain
|
0.00543
|
|
87
|
calmodulin binding
|
Function
|
Inferred
|
Explain
|
0.00536
|
|
88
|
GRK1 gene
|
Gene
|
Inferred
|
Explain
|
0.00526
|
|
89
|
Tamoxifen
|
Compound
|
Inferred
|
Explain
|
0.00517
|
|
90
|
inactivation of MAPK activity
|
Function
|
Inferred
|
Explain
|
0.00510
|
|
91
|
Protein kinase, ATP binding site
|
Domain
|
Inferred
|
Explain
|
0.00494
|
|
92
|
7-ethyl-10-hydroxycamptothecin
|
Compound
|
Inferred
|
Explain
|
0.00490
|
|
93
|
SNCB gene
|
Gene
|
Inferred
|
Explain
|
0.00485
|
|
94
|
Serine/threonine protein kinase, active site
|
Domain
|
Inferred
|
Explain
|
0.00483
|
|
95
|
GNAS gene
|
Gene
|
Inferred
|
Explain
|
0.00477
|
|
96
|
DMAP1 gene
|
Gene
|
Inferred
|
Explain
|
0.00470
|
|
97
|
Protein kinase, core
|
Domain
|
Inferred
|
Explain
|
0.00462
|
|
98
|
Protein Binding
|
Function
|
Inferred
|
Explain
|
0.00447
|
|
99
|
Cell Nucleus
|
Component
|
Inferred
|
Explain
|
0.00447
|
|
100
|
PLCB1 gene
|
Gene
|
Inferred
|
Explain
|
0.00444
|