PRF1 gene

Gene • C1418887

Synonyms

PRF1 gene • Perforin • PERFORIN 1 • PORE-FORMING PROTEIN • P1 • perforin 1 (pore forming protein) • PFP • HPLH2 • PFN1 • PRF1 • perforin 1 (preforming protein)

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    integral to membrane    Cell membrane    extracellular region    calcium ion binding    Apoptosis    Tamoxifen    Arsenic    testosterone enanthate    Autistic Disorder    Endosomes    ZM 182780    Azacitidine    CALR gene    Natural killer cell mediated cytotoxicity - Homo sapiens (human)    cytoplasmic membrane-bounded vesicle    response to ethanol    KEGG:hsa05416    protein homooligomerization    cellular defense response   

Related concepts

# Concept name Type Relation Support Score
1 cytolytic granule Component Known Explain 3.03264
2 HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2 Disease Known Explain 2.78241
3 defense response to tumor cell Function Known Explain 2.57114
4 wide pore channel activity Function Known Explain 2.23386
5 Cavity of endosome Component Known Explain 2.06586
6 Lymphoma, Non-Hodgkin Disease Known Explain 1.54719
7 immune response to tumor cell Function Known Explain 1.27708
8 GZMB gene Gene Known Explain 0.76454
9 Allograft rejection - Homo sapiens (human) Pathway Known Explain 0.73130
10 Lymphohistiocytosis, Hemophagocytic Disease Inferred Explain 0.71494
11 Type I diabetes mellitus - Homo sapiens (human) Pathway Known Explain 0.66637
12 Graft-versus-host disease - Homo sapiens (human) Pathway Known Explain 0.66574
13 defense response to virus Function Known Explain 0.64447
14 pathologic cytolysis Function Known Explain 0.59210
15 SRGN gene Gene Known Explain 0.56912
16 Autoimmune thyroid disease - Homo sapiens (human) Pathway Known Explain 0.54623
17 DDX24 gene Gene Known Explain 0.53849
18 KEGG:hsa05416 Pathway Known Explain 0.40108
19 response to tumor cell Function Inferred Explain 0.37507
20 cellular defense response Function Known Explain 0.37463
21 Circadian Rhythms Function Known Explain 0.36992
22 response to ethanol Function Known Explain 0.33502
23 protein homooligomerization Function Known Explain 0.32671
24 Natural killer cell mediated cytotoxicity - Homo sapiens (human) Pathway Known Explain 0.25283
25 cytoplasmic membrane-bounded vesicle Component Known Explain 0.23445
26 CALR gene Gene Known Explain 0.19784
27 Azacitidine Compound Known Explain 0.17490
28 gap junction hemi-channel activity Function Inferred Explain 0.16607
29 ZM 182780 Compound Known Explain 0.15047
30 Endosomes Component Known Explain 0.12032
31 gap junction channel activity Function Inferred Explain 0.11002
32 Autistic Disorder Disease Known Explain 0.08891
33 porin activity Function Inferred Explain 0.07902
34 intracellular organelle lumen Component Inferred Explain 0.07142
35 testosterone enanthate Compound Known Explain 0.06737
36 Arsenic Compound Known Explain 0.06712
37 Tamoxifen Compound Known Explain 0.06203
38 Apoptosis Function Known Explain 0.06094
39 channel activity Function Inferred Explain 0.06060
40 Lysosomes Component Inferred Explain 0.05905
41 endosomal part Component Inferred Explain 0.05687
42 Ki-1+ Anaplastic Large Cell Lymphoma Disease Inferred Explain 0.04891
43 calcium ion binding Function Known Explain 0.04145
44 defense response Function Inferred Explain 0.03893
45 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Disease Inferred Explain 0.03705
46 T-Cell Lymphoma Disease Inferred Explain 0.03649
47 B-Cell Lymphomas Disease Inferred Explain 0.02538
48 Burkitt Lymphoma Disease Inferred Explain 0.02443
49 HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 3 Disease Inferred Explain 0.02012
50 Cell membrane Component Known Explain 0.02007
51 Histiocytosis, Non-Langerhans-Cell Disease Inferred Explain 0.01968
52 Hemophagocytic lymphohistiocytosis, familial, 4 Disease Inferred Explain 0.01959
53 extracellular region Component Known Explain 0.01882
54 RAD54L gene Gene Inferred Explain 0.01864
55 natural killer cell mediated immune response to tumor cell Disease Inferred Explain 0.01856
56 Lymphoma, Follicular Disease Inferred Explain 0.01815
57 T cell mediated immune response to tumor cell Function Inferred Explain 0.01733
58 tolerance induction to tumor cell Function Inferred Explain 0.01728
59 Protein Binding Function Known Explain 0.01703
60 APOB gene Gene Inferred Explain 0.01420
61 GRISCELLI SYNDROME, TYPE 2 Disease Inferred Explain 0.01410
62 INS gene Gene Inferred Explain 0.01380
63 MICA gene Gene Inferred Explain 0.01376
64 integral to membrane Component Known Explain 0.01329
65 PANX3 gene Gene Inferred Explain 0.01239
66 PANX2 gene Gene Inferred Explain 0.01182
67 CASP10 gene Gene Inferred Explain 0.00883
68 Lymphoma Disease Inferred Explain 0.00690
69 PANX1 gene Gene Inferred Explain 0.00680
70 Antigen processing and presentation - Homo sapiens (human) Pathway Inferred Explain 0.00578
71 T cell tolerance induction to tumor cell Function Inferred Explain 0.00568
72 UNC13D gene Gene Inferred Explain 0.00532
73 HLA-DOA gene Gene Inferred Explain 0.00531
74 cellular response to tumor cell Function Inferred Explain 0.00522
75 HLA-DMA gene Gene Inferred Explain 0.00498
76 p53, tetramerisation Domain Inferred Explain 0.00491
77 detection of tumor cell Function Inferred Explain 0.00487
78 HLA-DOB gene Gene Inferred Explain 0.00472
79 HLA-DMB gene Gene Inferred Explain 0.00470
80 HLA-DQA2 gene Gene Inferred Explain 0.00465
81 HLA-DRB5 gene Gene Inferred Explain 0.00464
82 HLA-DRA gene Gene Inferred Explain 0.00440
83 HLA-DRB4 gene Gene Inferred Explain 0.00438
84 HLA-G gene Gene Inferred Explain 0.00417
85 HLA-DPA1 gene Gene Inferred Explain 0.00416
86 HLA-DRB3 gene Gene Inferred Explain 0.00410
87 HLA-E gene Gene Inferred Explain 0.00407
88 HLA-F gene Gene Inferred Explain 0.00381
89 HLA-DQA1 gene Gene Inferred Explain 0.00369
90 HLA-DQB1 gene Gene Inferred Explain 0.00337
91 HLA-DRB1 gene Gene Inferred Explain 0.00336
92 Immune response Function Inferred Explain 0.00313
93 HLA-DPB1 gene Gene Inferred Explain 0.00308
94 cleavage of lamin Function Inferred Explain 0.00289
95 HLA-A gene Gene Inferred Explain 0.00266
96 HLA-C gene Gene Inferred Explain 0.00261
97 GJC2 gene Gene Inferred Explain 0.00257
98 peripheral tolerance induction Function Inferred Explain 0.00256
99 Histiocytosis Disease Inferred Explain 0.00252
100 Sea-Blue Histiocyte Syndrome Disease Inferred Explain 0.00244