GCLC gene

Gene • C1415097

Definition

This gene plays a role in the detoxification of endogenous reactive oxygen species. It is also involved in drug and xenobiotic metabolism.

Synonyms

GCLC gene • GCS • GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT • Glutamate-Cysteine Ligase, Catalytic Subunit Gene • GAMMA-GLUTAMYLCYSTEINE SYNTHETASE, CATALYTIC SUBUNIT • GCLC • GLCLC

Linked items?Related concepts, ordered by their global importance in the network.

Cytoplasm    Cyclosporine    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    Benzo(a)pyrene    Tetrachlorodibenzodioxin    ATP binding    nucleotide binding    Cytoplasmic matrix    arsenic trioxide    tert-Butylhydroperoxide    Adenosine Triphosphate    sodium arsenite    bisphenol A    Doxorubicin    Adenosine Diphosphate    resveratrol    Quercetin    Arsenic    Curcumin    Cisplatin   

Related concepts

# Concept name Type Relation Support Score
1 buthionine sulfoximine ethyl ester Compound Known Explain 0.33148
2 gamma-L-Glutamyl-L-cysteine Compound Known Explain 0.30335
3 Suprofen Compound Known Explain 0.29862
4 regulation of mitochondrial depolarization Function Known Explain 0.26906
5 glutamate-cysteine ligase complex Component Known Explain 0.25910
6 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO, 1 Disease Known Explain 0.25879
7 2,4,5-Trichlorophenoxyacetic Acid Compound Known Explain 0.24397
8 response to xenobiotic stimulus Function Known Explain 0.24326
9 response to nitrosative stress Function Known Explain 0.23819
10 glutamate-cysteine ligase activity Function Known Explain 0.23335
11 S-sulindac Compound Known Explain 0.21979
12 Clobetasol Compound Known Explain 0.21934
13 Linoleic Acids, Conjugated Compound Known Explain 0.19807
14 L-ascorbic acid metabolic process Function Known Explain 0.18864
15 GCLM gene Gene Inferred Explain 0.18802
16 glutamate binding Function Known Explain 0.18197
17 Coal Tar Compound Known Explain 0.17208
18 artesunate Compound Known Explain 0.17106
19 Alkylating Agents Compound Known Explain 0.16826
20 Ethacrynate Sodium Compound Known Explain 0.16422
21 2-tert-butylhydroquinone Compound Known Explain 0.14321
22 glutathione biosynthetic process Function Known Explain 0.13142
23 Thioctic Acid Compound Known Explain 0.13048
24 Ketoprofen Compound Known Explain 0.12688
25 gamma-Linolenic Acid Compound Known Explain 0.12033
26 response to arsenic Function Known Explain 0.11528
27 AMIF-72 Compound Known Explain 0.11519
28 Rokan Compound Known Explain 0.11445
29 Cysteine Metabolism Pathway Function Known Explain 0.11148
30 negative regulation of protein ubiquitination Function Known Explain 0.11082
31 regulation of blood vessel size Function Known Explain 0.10526
32 ADP binding Function Known Explain 0.10501
33 2-Acetylaminofluorene Compound Known Explain 0.09240
34 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Function Known Explain 0.08896
35 Glutamate Metabolism Pathway Function Known Explain 0.08859
36 Cysteine Compound Known Explain 0.08809
37 Synflex Compound Known Explain 0.08773
38 Eicosapentaenoic Acid Compound Known Explain 0.08252
39 Chlorambucil Compound Known Explain 0.08199
40 Amino Acid Metabolism, Inborn Errors Disease Known Explain 0.08038
41 myricetin Compound Known Explain 0.07990
42 alpha-Linolenic Acid Compound Known Explain 0.07607
43 Staurosporine Compound Known Explain 0.06501
44 Apigenin Compound Known Explain 0.06231
45 Anemia, Hemolytic Disease Known Explain 0.05972
46 negative regulation of neuron apoptosis Function Known Explain 0.05758
47 Glutathione Metabolism Pathway Function Known Explain 0.05515
48 ZD1839 Compound Known Explain 0.05369
49 Myocardial Infarction Disease Known Explain 0.05355
50 BMS 247616 Compound Known Explain 0.05341
51 triacsin C Compound Known Explain 0.05228
52 Glutamic Acid Compound Known Explain 0.05065
53 coenzyme binding Function Known Explain 0.05018
54 kaempferol Compound Known Explain 0.04670
55 response to heat Function Known Explain 0.04624
56 sodium arsenate Compound Known Explain 0.04588
57 Vincristine Compound Known Explain 0.04076
58 nickel chloride Compound Known Explain 0.04073
59 Glutathione Compound Known Explain 0.04015
60 Acrolein Compound Known Explain 0.03999
61 Carcinoma, Non-Small-Cell Lung Disease Known Explain 0.03735
62 Antimony Compound Known Explain 0.03615
63 Phenylpropionates Compound Inferred Explain 0.03373
64 cell redox homeostasis Function Known Explain 0.03164
65 response to hormone stimulus Function Known Explain 0.03129
66 MMA(III) Compound Known Explain 0.03113
67 ABCC1 gene Gene Inferred Explain 0.03029
68 Acetylcysteine Compound Known Explain 0.02977
69 beta-Naphthoflavone Compound Known Explain 0.02799
70 Glutamate--cysteine ligase Domain Inferred Explain 0.02798
71 Arachidonic Acid Compound Known Explain 0.02716
72 Hepatitis, Toxic Other Known Explain 0.02663
73 Sodium Diphenylhydantoinate Compound Known Explain 0.02654
74 Dimethylnitrosamine Compound Known Explain 0.02622
75 PD 98059 Compound Known Explain 0.02571
76 response to oxidative stress Function Known Explain 0.02532
77 Ibuprofen Compound Known Explain 0.02354
78 regulation of membrane depolarization Function Inferred Explain 0.02216
79 anti-apoptosis Function Known Explain 0.01961
80 Glutamate--cysteine ligase, monofunctional Domain Inferred Explain 0.01953
81 Xenobiotic Metabolism Function Known Explain 0.01896
82 Dust Other Known Explain 0.01893
83 Plant Extracts Compound Known Explain 0.01866
84 Ethinyl Estradiol Compound Known Explain 0.01753
85 Sulindac Compound Known Explain 0.01709
86 Glutamate--cysteine ligase related Domain Inferred Explain 0.01679
87 negative regulation of mitochondrial depolarization Function Inferred Explain 0.01620
88 Mercury Compound Known Explain 0.01610
89 protein heterodimerization activity Function Known Explain 0.01578
90 GSS gene Gene Inferred Explain 0.01504
91 Glutamate--cysteine ligase, plant Domain Inferred Explain 0.01484
92 Etoposide Compound Known Explain 0.01473
93 Glutamate--cysteine ligase, GCS2 Domain Inferred Explain 0.01460
94 ABCC2 gene Gene Inferred Explain 0.01459
95 cellular response to xenobiotic stimulus Function Inferred Explain 0.01428
96 positive regulation of mitochondrial depolarization Function Inferred Explain 0.01420
97 C1427707 Other Inferred Explain 0.01368
98 Folliculitis Disease Inferred Explain 0.01229
99 Glutamate-cysteine ligase catalytic subunit Domain Inferred Explain 0.01221
100 ascorbate glutathione cycle Function Inferred Explain 0.01209