WRN gene

Gene • C1337007

Definition

This gene is involved in DNA repair and the unwinding of DNA.

Synonyms

WRN gene • RECQ3 • RECQL2 • WRN • Werner Syndrome Gene • DNA HELICASE, RECQ-LIKE, TYPE 3 • RECQ PROTEIN-LIKE 2 • Werner syndrome, RecQ helicase-like

Linked items?Related concepts, ordered by their global importance in the network.

Cell Nucleus    Protein Binding    Cyclosporine    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    DNA Binding    Protoplasm    ATP binding    nucleotide binding    pirinixic acid    TP53 gene    Nucleoplasm    UBC gene    Cell Nucleolus    protein homodimerization activity    PARP1 gene    Etoposide    PRKDC gene    magnesium ion binding    PCNA gene    CDKN2A gene   

Related concepts

# Concept name Type Relation Support Score
1 ATP-dependent 3'-5' DNA helicase activity Function Known Explain 0.58230
2 3'-5' DNA helicase activity Function Known Explain 0.54266
3 RQC domain Domain Known Explain 0.47704
4 nucleolus to nucleoplasm transport Function Known Explain 0.44297
5 DNA helicase, ATP-dependent, RecQ type Domain Known Explain 0.39954
6 replicative cell aging Function Known Explain 0.37473
7 G-quadruplex DNA binding Function Known Explain 0.36505
8 replication fork processing Function Known Explain 0.34908
9 four-way junction helicase activity Function Known Explain 0.33613
10 Helicase/RNase D C-terminal, HRDC domain Domain Known Explain 0.32218
11 Werner Syndrome Disease Known Explain 0.31801
12 regulation of growth rate Function Known Explain 0.29602
13 bubble DNA binding Function Known Explain 0.29208
14 Y-form DNA binding Function Known Explain 0.28589
15 DNA helicase activity Function Known Explain 0.28005
16 HRDC-like Domain Known Explain 0.26955
17 BLM gene Gene Known Explain 0.26589
18 MutLalpha complex Component Known Explain 0.26096
19 multicellular organismal aging Function Known Explain 0.25798
20 3'-5' exonuclease Domain Known Explain 0.23565
21 response to UV-C Function Known Explain 0.22754
22 NLRP2 gene Gene Known Explain 0.21976
23 DNA synthesis during DNA repair Function Known Explain 0.19751
24 Cell Aging Function Known Explain 0.17753
25 WRNIP1 gene Gene Known Explain 0.16375
26 positive regulation of hydrolase activity Function Known Explain 0.13281
27 Amsacrine Compound Known Explain 0.13164
28 chromium hexavalent ion Compound Known Explain 0.12584
29 RAD52 gene Gene Known Explain 0.12090
30 ATP-dependent DNA helicase activity Function Known Explain 0.11750
31 3'-5' exonuclease activity Function Known Explain 0.11639
32 PRKAR1B gene Gene Known Explain 0.11219
33 POLD2 gene Gene Known Explain 0.10865
34 POT1 gene Gene Known Explain 0.10405
35 MDC1 gene Gene Known Explain 0.09722
36 Telomere Maintenance Function Known Explain 0.08970
37 Base Excision Repair Function Known Explain 0.08812
38 DNA/RNA helicase, DEAD/DEAH box type, N-terminal Domain Known Explain 0.08436
39 POLR1C gene Gene Known Explain 0.08374
40 CHAF1A gene Gene Known Explain 0.08244
41 POLB gene Gene Known Explain 0.07726
42 Helicase, superfamily 1/2, ATP-binding domain Domain Known Explain 0.07413
43 response to DNA damage stimulus Function Known Explain 0.07053
44 TERF2 gene Gene Known Explain 0.07049
45 cellular response to starvation Function Known Explain 0.06942
46 Polynucleotidyl transferase, ribonuclease H fold Domain Known Explain 0.06920
47 nuclear transport Function Inferred Explain 0.06806
48 exonuclease activity Function Known Explain 0.06620
49 DNA/RNA helicase, C-terminal Domain Known Explain 0.06451
50 FEN1 gene Gene Known Explain 0.06440
51 Recombination, Genetic Function Known Explain 0.06372
52 DEAD-like helicase, N-terminal Domain Known Explain 0.06350
53 NBN gene Gene Known Explain 0.06198
54 hydroquinone Compound Known Explain 0.05953
55 ATP Hydrolysis Function Known Explain 0.05930
56 RPA2 gene Gene Known Explain 0.05430
57 Aging Function Known Explain 0.05384
58 WDR48 gene Gene Known Explain 0.05104
59 RPA1 gene Gene Known Explain 0.04945
60 helicase activity Function Known Explain 0.04827
61 ATR gene Gene Known Explain 0.04791
62 manganese ion binding Function Known Explain 0.04671
63 DNA metabolism Function Known Explain 0.04653
64 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Function Known Explain 0.04628
65 DNA helicase, ATP-dependent, RecQ type, bacterial Domain Inferred Explain 0.04527
66 XRCC5 gene Gene Known Explain 0.04139
67 cellular metabolic process Function Known Explain 0.04105
68 VCP gene Gene Known Explain 0.03980
69 TBRG1 gene Gene Inferred Explain 0.03808
70 replication fork processing at rDNA locus Function Inferred Explain 0.03745
71 protein complex binding Function Known Explain 0.03374
72 H2AFX gene Gene Known Explain 0.03351
73 DNA biosynthesis Function Known Explain 0.03314
74 XRCC6 gene Gene Known Explain 0.03296
75 Benzene Compound Known Explain 0.03073
76 response to oxidative stress Function Known Explain 0.02950
77 ATM gene Gene Known Explain 0.02926
78 SIRT1 gene Gene Known Explain 0.02921
79 adenosinetriphosphatase activity Function Known Explain 0.02813
80 PCNA gene Gene Known Explain 0.02750
81 Ribonuclease D Domain Inferred Explain 0.02540
82 RECQL4 gene Gene Inferred Explain 0.02486
83 ROMO1 gene Gene Inferred Explain 0.02422
84 Centrosome Component Known Explain 0.02421
85 structure-specific DNA binding Function Inferred Explain 0.02297
86 PARP1 gene Gene Known Explain 0.02260
87 DNA secondary structure binding Function Inferred Explain 0.02252
88 PRKDC gene Gene Known Explain 0.02225
89 DNA helicase, Holliday junction RuvB type Domain Inferred Explain 0.02149
90 regulation of apoptosis Function Known Explain 0.02109
91 CDKN2A gene Gene Known Explain 0.02077
92 maintenance of fidelity during DNA-dependent DNA replication Function Inferred Explain 0.02073
93 negative regulation of growth rate Function Inferred Explain 0.02001
94 IPR022758 Domain Inferred Explain 0.01991
95 RECQL gene Gene Inferred Explain 0.01914
96 positive regulation of growth rate Function Inferred Explain 0.01871
97 maintenance of rDNA Function Inferred Explain 0.01817
98 DNA helicase, Holliday junction RuvB type, N-terminal Domain Inferred Explain 0.01766
99 Etoposide Compound Known Explain 0.01712
100 DNA helicase, Holliday junction RuvB type, C-terminal Domain Inferred Explain 0.01590