CYP3A4 gene

Gene • C1176140

Definition

This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates and xenobiotics.

Synonyms

CYP3A4 gene • NIFEDIPINE OXIDASE • CYP3A4 • CYP3A • CYTOCHROME P450, SUBFAMILY IIIA, POLYPEPTIDE 4 • CYP3 • CYTOCHROME P450PCN1 • P450, FAMILY III • GLUCOCORTICOID-INDUCIBLE P450 • P450-III, STEROID-INDUCIBLE • P450C3 • cytochrome P450, family 3, subfamily A, polypeptide 4 • Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene

Linked items?Related concepts, ordered by their global importance in the network.

Cytoplasm    integral to membrane    Membrane    Metal Ion Binding    arsenic trioxide    Selenium    Vitamin E    Oxidation-Reduction    Tretinoin    Fluorouracil    Estradiol    Endoplasmic Reticulum    Water    Progesterone    sodium arsenite    Calcitriol    bisphenol A    Genistein    oxidoreductase activity    resveratrol   

Related concepts

# Concept name Type Relation Support Score
1 CYP3A5 gene Gene Inferred Explain 0.11075
2 CYP2D6 gene Gene Inferred Explain 0.09653
3 CYP2C19 gene Gene Inferred Explain 0.09392
4 CYP2B6 gene Gene Inferred Explain 0.09389
5 CYP1A2 gene Gene Inferred Explain 0.08108
6 Tinidazole Compound Known Explain 0.07932
7 Isradipine Compound Known Explain 0.07768
8 testosterone 6-beta-hydroxylase activity Function Known Explain 0.07662
9 Sodium Cholate Compound Known Explain 0.07618
10 Rifabutin Compound Known Explain 0.07606
11 1-hydroxymethylmidazolam Compound Known Explain 0.07569
12 6 beta-hydroxytestosterone Compound Known Explain 0.07569
13 azamulin Compound Known Explain 0.07569
14 CYP2C9 gene Gene Inferred Explain 0.07567
15 Catatoxic Steroids Compound Known Explain 0.07441
16 CQA 206-291 Compound Known Explain 0.07441
17 Eucalyptol Compound Known Explain 0.07441
18 norbuprenorphine Compound Known Explain 0.07360
19 KW 4354 Compound Known Explain 0.07360
20 estradiol-17 beta-3-methyl ether Compound Known Explain 0.07358
21 butachlor Compound Known Explain 0.07348
22 taurochenodeoxycholate 6alpha-hydroxylase activity Function Known Explain 0.07315
23 albendazole monooxygenase activity Function Known Explain 0.07315
24 quinine 3-monooxygenase activity Function Known Explain 0.07315
25 schizandrin A Known Explain 0.07283
26 pretilachlor Compound Known Explain 0.07283
27 compactin Known Explain 0.07283
28 gugulu extract Compound Known Explain 0.07283
29 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide Compound Known Explain 0.07277
30 pimobendan Compound Known Explain 0.07213
31 naringin Compound Known Explain 0.07109
32 FK 463 Compound Known Explain 0.07056
33 isosafrole Compound Known Explain 0.07056
34 6 beta-hydroxycortisol Compound Known Explain 0.06948
35 1,2-dilauroylphosphatidylcholine Compound Known Explain 0.06929
36 CYP2E1 gene Gene Inferred Explain 0.06273
37 CYP2C8 gene Gene Inferred Explain 0.06139
38 Triazolam Compound Known Explain 0.05427
39 CYP2A6 gene Gene Inferred Explain 0.05381
40 3-methoxymorphinan Compound Known Explain 0.05324
41 carbosulfan Compound Known Explain 0.05313
42 dechloroethylcyclophosphamide Compound Known Explain 0.05313
43 Nitrendipine Compound Known Explain 0.05280
44 Alfenta Compound Known Explain 0.05238
45 aflatoxin G1 Compound Known Explain 0.05222
46 voriconazole Compound Known Explain 0.05210
47 dexamethasone 21-tributylacetate Compound Known Explain 0.05203
48 1,2,3,5-tetrachlorobenzene Compound Known Explain 0.05180
49 NOC 18 Compound Known Explain 0.05169
50 N-(4-cyano-benzo(b)thiophene-2-carbonyl)guanidine Compound Known Explain 0.05166
51 droloxifene Compound Known Explain 0.05163
52 N-desmethyltamoxifen Compound Known Explain 0.05163
53 Phenelzine Compound Known Explain 0.05153
54 13-cis-retinal Compound Known Explain 0.04902
55 NR1I2 gene Gene Inferred Explain 0.04843
56 felbamate Compound Known Explain 0.04840
57 vitamin D3 25-hydroxylase activity Function Known Explain 0.04820
58 1,2-oleoylphosphatidylcholine Compound Known Explain 0.04695
59 Parlodel Compound Known Explain 0.04691
60 VX 478 Compound Known Explain 0.04660
61 Dextrorphan Compound Known Explain 0.04206
62 N-ethyl-3-toluamide Compound Known Explain 0.04202
63 Moricizine Compound Known Explain 0.04167
64 shengmaisan Compound Known Explain 0.04157
65 4-ipomeanol Compound Known Explain 0.04155
66 fenproporex Compound Known Explain 0.04149
67 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline Compound Known Explain 0.04114
68 Granisetron Compound Known Explain 0.04039
69 thiocoraline Compound Known Explain 0.04019
70 MJ-9022-1 Compound Known Explain 0.04007
71 CYP1A1 gene Gene Inferred Explain 0.03978
72 quetiapine Compound Known Explain 0.03970
73 Etonogestrel Compound Known Explain 0.03950
74 stiripentol Compound Known Explain 0.03949
75 carbamazepine epoxide Compound Known Explain 0.03934
76 Sulfamethazine Compound Known Explain 0.03854
77 bioresmethrin Compound Known Explain 0.03848
78 bifonazole Compound Known Explain 0.03841
79 Troleandomycin Compound Known Explain 0.03830
80 indomethacin phenethylamide Compound Known Explain 0.03811
81 Econazole Compound Known Explain 0.03761
82 RPR 121056 Compound Known Explain 0.03730
83 schizandrin B Compound Known Explain 0.03702
84 CYP3A7 gene Gene Inferred Explain 0.03613
85 Mefloquine Compound Known Explain 0.03601
86 Amphotericin B Compound Known Explain 0.03594
87 mepirodipine Compound Known Explain 0.03576
88 Alprazolam Compound Known Explain 0.03545
89 Posicor Compound Known Explain 0.03542
90 8-phenyltheophylline Compound Known Explain 0.03464
91 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime Compound Known Explain 0.03398
92 GBR 12909 Compound Known Explain 0.03330
93 CYP1B1 gene Gene Inferred Explain 0.03292
94 Carbofuran Compound Known Explain 0.03272
95 CYP2C18 gene Gene Inferred Explain 0.03264
96 norfluoxetine Compound Known Explain 0.03185
97 nefazodone Compound Known Explain 0.03143
98 acetochlor Compound Known Explain 0.03130
99 Cisapride Compound Known Explain 0.03124
100 Metyrapone Compound Known Explain 0.03116