integral to membrane

Component • C1167322

Definition

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded i

Synonyms

integral to membrane • transmembrane

Linked items?Related concepts, ordered by their global importance in the network.

integral to plasma membrane    EGFR gene    BCL2 gene    CYP3A4 gene    7TM GPCR, rhodopsin-like    HLA-B gene    BAX gene    CFTR gene    ERBB2 gene    APP gene    BCL2L1 gene    TGFBR1 gene    ABCB1 gene    UGT1A1 gene    FAS gene    CDH1 gene    PSEN1 gene    Olfactory receptor    SMAD1 gene    FGFR2 gene   

Related concepts

# Concept name Type Relation Support Score
1 Membrane Component Inferred Explain 0.09113
2 Cell membrane Component Inferred Explain 0.03107
3 receptor activity Function Inferred Explain 0.02900
4 olfactory receptor activity Function Inferred Explain 0.02608
5 Smell Perception Function Inferred Explain 0.02501
6 Response to stimulus physiology Function Inferred Explain 0.02209
7 Olfactory transduction - Homo sapiens (human) Pathway Inferred Explain 0.02038
8 G-protein coupled receptor protein signaling pathway Function Inferred Explain 0.01981
9 7TM GPCR, rhodopsin-like Domain Known Explain 0.01719
10 GPCR, rhodopsin-like superfamily Domain Inferred Explain 0.01156
11 Olfactory receptor Domain Known Explain 0.01142
12 Cyclosporine Compound Inferred Explain 0.00638
13 Transmembrane Transport Function Inferred Explain 0.00638
14 G-protein coupled receptor activity Function Inferred Explain 0.00586
15 Ion Transport Function Inferred Explain 0.00573
16 Endoplasmic Reticulum Component Inferred Explain 0.00512
17 Endoplasmic reticulum, membrane Component Inferred Explain 0.00496
18 Biological Transport Function Inferred Explain 0.00401
19 Golgi Apparatus Component Inferred Explain 0.00368
20 Benzo(a)pyrene Compound Inferred Explain 0.00345
21 Protein Binding Function Inferred Explain 0.00330
22 Golgi membrane Component Inferred Explain 0.00316
23 Tetrachlorodibenzodioxin Compound Inferred Explain 0.00290
24 Cell Adhesion Function Inferred Explain 0.00266
25 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Inferred Explain 0.00263
26 homophilic cell adhesion Function Inferred Explain 0.00254
27 transporter activity Function Inferred Explain 0.00240
28 sodium ion transport Function Inferred Explain 0.00236
29 pirinixic acid Compound Inferred Explain 0.00222
30 Selenite Compound Inferred Explain 0.00214
31 Calcium Valproate Compound Inferred Explain 0.00210
32 Aflatoxin B1 Compound Inferred Explain 0.00197
33 Mitochondria Component Inferred Explain 0.00197
34 Cytoplasm Component Inferred Explain 0.00196
35 calcium ion binding Function Inferred Explain 0.00194
36 Physiological Processes Function Inferred Explain 0.00192
37 Estradiol Compound Inferred Explain 0.00190
38 molecular_function Function Inferred Explain 0.00190
39 5-Hydroxytryptamine receptor Domain Known Explain 0.00186
40 potassium ion transport Function Inferred Explain 0.00176
41 ion channel activity Function Inferred Explain 0.00170
42 Major facilitator superfamily MFS-1 Domain Inferred Explain 0.00167
43 Metal Ion Binding Function Inferred Explain 0.00160
44 integral to plasma membrane Component Known Explain 0.00156
45 Asbestos, Crocidolite Compound Inferred Explain 0.00154
46 Immunoglobulin-like fold Domain Inferred Explain 0.00150
47 voltage-gated ion channel activity Function Inferred Explain 0.00149
48 arsenic trioxide Compound Inferred Explain 0.00143
49 Intercellular Junctions Other Inferred Explain 0.00142
50 Signal Transduction Function Inferred Explain 0.00141
51 Immunoglobulin-like Domain Inferred Explain 0.00132
52 glycosyltransferase activity Function Inferred Explain 0.00130
53 Cell Nucleus Component Inferred Explain 0.00129
54 Selenium Compound Inferred Explain 0.00127
55 phosphoenolpyruvate-dependent sugar phosphotransferase system Function Inferred Explain 0.00126
56 protein transport Function Inferred Explain 0.00125
57 Inner mitochondrial membrane Component Inferred Explain 0.00121
58 Binding (Molecular Function) Function Inferred Explain 0.00121
59 calcium ion transport Function Inferred Explain 0.00120
60 sugar binding Function Inferred Explain 0.00117
61 cation transport Function Inferred Explain 0.00115
62 transferase activity Function Inferred Explain 0.00114
63 sodium:hydrogen antiporter activity Function Inferred Explain 0.00112
64 Vitamin E Compound Inferred Explain 0.00111
65 Chemokine receptor Domain Known Explain 0.00111
66 extracellular region Component Inferred Explain 0.00105
67 Calcitriol Compound Inferred Explain 0.00105
68 cellular_component Component Inferred Explain 0.00103
69 tert-Butylhydroperoxide Compound Inferred Explain 0.00102
70 Immunoglobulin subtype Domain Inferred Explain 0.00102
71 Gram-negative-bacterium-type cell wall Component Inferred Explain 0.00101
72 P2 purinoceptor Domain Known Explain 0.00101
73 symporter activity Function Inferred Explain 0.00099
74 Taste Perception Function Inferred Explain 0.00099
75 Neurotransmitter-gated ion-channel, conserved site Domain Known Explain 0.00099
76 Opsin Domain Known Explain 0.00098
77 Neuroactive ligand-receptor interaction - Homo sapiens (human) Pathway Inferred Explain 0.00097
78 Amiodarone Compound Inferred Explain 0.00092
79 GPCR, family 3, C-terminal Domain Known Explain 0.00092
80 Ion transport Domain Inferred Explain 0.00092
81 ATP binding Function Inferred Explain 0.00090
82 Hydralazine Compound Inferred Explain 0.00089
83 regulation of pH Function Inferred Explain 0.00088
84 membrane fraction Component Inferred Explain 0.00087
85 Adenosine receptor Domain Known Explain 0.00085
86 nucleotide binding Function Inferred Explain 0.00085
87 TMC Domain Known Explain 0.00084
88 purinergic nucleotide receptor activity, G-protein coupled Function Inferred Explain 0.00084
89 zinc ion binding Function Inferred Explain 0.00082
90 GPCR, family 3, conserved site Domain Known Explain 0.00082
91 multicellular organismal development Function Inferred Explain 0.00081
92 hydrolase activity Function Inferred Explain 0.00081
93 Fluorouracil Compound Inferred Explain 0.00080
94 neuropeptide signaling pathway Function Inferred Explain 0.00079
95 Neurotransmitter-gated ion-channel transmembrane region Domain Inferred Explain 0.00079
96 Taste transduction - Homo sapiens (human) Pathway Inferred Explain 0.00078
97 Peptidase S54, rhomboid Domain Known Explain 0.00077
98 voltage-gated calcium channel activity Function Inferred Explain 0.00077
99 Adrenergic receptor Domain Known Explain 0.00077
100 Synaptic Transmission Function Inferred Explain 0.00076