BAX gene

Gene • C0812198

Definition

This gene is involved in the regulation of apoptosis by binding p53 protein, which accelerates this mechanism of cell death.

Synonyms

BAX gene • BCL2-Associated X Protein Gene • BCL2-ASSOCIATED X PROTEIN • BAX • BCL2L4

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    Cytoplasm    integral to membrane    Membrane    Cyclosporine    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    Benzo(a)pyrene    Tetrachlorodibenzodioxin    Cytoplasmic matrix    Estradiol    arsenic trioxide    Aflatoxin B1    Selenium    Vitamin E    Mitochondria    Tretinoin    Fluorouracil    tert-Butylhydroperoxide    Selenite    Endoplasmic Reticulum   

Related concepts

# Concept name Type Relation Support Score
1 BCL2 gene Gene Known Explain 0.13344
2 CASP3 gene Gene Inferred Explain 0.09798
3 BCL2L1 gene Gene Known Explain 0.07353
4 CASP9 gene Gene Inferred Explain 0.05372
5 CYCS gene Gene Inferred Explain 0.04687
6 nuclear fragmentation during apoptosis Function Known Explain 0.04229
7 release of matrix enzymes from mitochondria Function Known Explain 0.03883
8 polysaccharide peptide Compound Known Explain 0.03769
9 Quinacrine Compound Known Explain 0.03703
10 BAK1 gene Gene Known Explain 0.03663
11 cis-bis(3-aminoflavone)dichloroplatinum(II) Compound Known Explain 0.03656
12 BID gene Gene Known Explain 0.03543
13 xanthoangelol Compound Known Explain 0.03539
14 4-amino-1,8-naphthalimide Compound Known Explain 0.03536
15 Aminacrine Compound Known Explain 0.03523
16 phytosphingosine Compound Known Explain 0.03487
17 3,4,5,4'-tetramethoxystilbene Compound Known Explain 0.03453
18 establishment or maintenance of transmembrane electrochemical gradient Function Known Explain 0.03432
19 cleavage of lamin Function Known Explain 0.03405
20 N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide Compound Known Explain 0.03392
21 apoptotic mitochondrial changes Function Known Explain 0.03353
22 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline Compound Known Explain 0.03328
23 PARP1 gene Gene Inferred Explain 0.03324
24 tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex Compound Known Explain 0.03293
25 (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane Compound Known Explain 0.03238
26 hyperoside Compound Known Explain 0.03217
27 MCL1 gene Gene Known Explain 0.03181
28 grifolin Compound Known Explain 0.03102
29 BH3 domain binding Function Known Explain 0.03092
30 acetyl-aspartyl-glutamyl-valyl-aspartal Compound Known Explain 0.03081
31 GW8510 Compound Known Explain 0.03081
32 mitochondrial permeability transition pore complex Component Known Explain 0.03066
33 Scutellaria barbata extract Compound Known Explain 0.03056
34 Apitoxin Compound Known Explain 0.03010
35 dideoxypetrosynol A Compound Known Explain 0.02993
36 transformed cell apoptosis Function Known Explain 0.02988
37 mitochondrial fragmentation during apoptosis Function Known Explain 0.02956
38 regulation of protein heterodimerization activity Function Known Explain 0.02946
39 2-amino-4-hydroxy-6-formylpteridine Compound Known Explain 0.02921
40 Vindesine Compound Known Explain 0.02913
41 BCL2-like apoptosis inhibitor Domain Known Explain 0.02905
42 4,5,6,7-tetrabromobenzotriazole Compound Known Explain 0.02894
43 diazene Compound Known Explain 0.02888
44 gallium nitrate Compound Known Explain 0.02883
45 tripchlorolide Compound Known Explain 0.02865
46 N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugate Compound Known Explain 0.02848
47 Acridine Orange Compound Known Explain 0.02847
48 PK 11195 Compound Known Explain 0.02843
49 7-hydroxycoumarin Compound Known Explain 0.02834
50 AN 215 Compound Known Explain 0.02833
51 periodate-oxidized adenosine Compound Known Explain 0.02817
52 IPR020726 Domain Known Explain 0.02779
53 Cantharides Organism Known Explain 0.02774
54 mafosfamide Compound Known Explain 0.02771
55 IDN 5109 Compound Known Explain 0.02722
56 Apoptosis regulator Bcl-2, BH Domain Known Explain 0.02721
57 echinocystic acid Compound Known Explain 0.02711
58 codonoposide Compound Known Explain 0.02711
59 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone Compound Known Explain 0.02710
60 Epothilones Compound Known Explain 0.02684
61 fraxetin Compound Known Explain 0.02647
62 IPR020717 Domain Known Explain 0.02643
63 S-(1,2-dichlorovinyl)cysteine Compound Known Explain 0.02639
64 chan su Compound Known Explain 0.02638
65 gamboge acid Compound Known Explain 0.02625
66 B cell apoptosis Function Known Explain 0.02622
67 Amifostine Compound Known Explain 0.02619
68 BAY 43-9006 Compound Known Explain 0.02618
69 shogaol Compound Known Explain 0.02591
70 Buserelin Compound Known Explain 0.02583
71 beta-solamarine Compound Known Explain 0.02571
72 Ytterbium Compound Known Explain 0.02535
73 beta Sitosterol Compound Known Explain 0.02516
74 Lymphoma, T-Cell, Cutaneous Disease Known Explain 0.02494
75 ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate Compound Known Explain 0.02492
76 IPR020728 Domain Known Explain 0.02485
77 honokiol Compound Known Explain 0.02479
78 SK-7041 Compound Known Explain 0.02478
79 hesperetin Compound Known Explain 0.02453
80 D 21266 Compound Known Explain 0.02448
81 Asbestos, Amosite Compound Known Explain 0.02429
82 carboxycinnamic acid bishydroxamide Compound Known Explain 0.02428
83 malvidin chloride Compound Known Explain 0.02414
84 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone Compound Known Explain 0.02413
85 induction of retinal programmed cell death Function Known Explain 0.02404
86 theaflavin Compound Known Explain 0.02402
87 CASP8 gene Gene Inferred Explain 0.02382
88 2,4-thiazolidinedione Compound Known Explain 0.02298
89 activation of caspase activity by cytochrome c Function Known Explain 0.02294
90 ellipticine Compound Known Explain 0.02196
91 mono-(2-ethylhexyl)phthalate Compound Known Explain 0.02164
92 LAQ824 Compound Known Explain 0.02154
93 Caryolysine Compound Known Explain 0.02130
94 ursolic acid Compound Known Explain 0.02124
95 esculetin Compound Known Explain 0.02114
96 Doxazosin Mesylate Compound Known Explain 0.02113
97 AGN 190168 Compound Known Explain 0.02110
98 delphinidin Compound Known Explain 0.02102
99 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole Compound Known Explain 0.02078
100 Leuprolide Compound Known Explain 0.02052