PTEN gene

Gene • C0694888

Definition

This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.

Synonyms

PTEN gene • PHOSPHATASE AND TENSIN HOMOLOG • TEP1 • PTEN1 • MUTATED IN MULTIPLE ADVANCED CANCERS 1 • MMAC1 • PTEN • phosphatase and tensin homolog (mutated in multiple advanced cancers 1) • Phosphatase and Tensin Homolog (Mutated in Multiple Advanced Cancers 1) Gene • PHOSPHATASE AND TENSIN HOMOLOG DELETED ON CHROMOSOME 10

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    Cell Nucleus    Cytoplasm    Cytoplasmic matrix    Mitochondria    Fluorouracil    tert-Butylhydroperoxide    hydrolase activity    TP53 gene    decitabine    Water    sodium arsenite    bisphenol A    Doxorubicin    Genistein    ESR1 gene    resveratrol    Quercetin    GSK3B gene    AKT1 gene   

Related concepts

# Concept name Type Relation Support Score
1 Anisometropia Disease Known Explain 0.59251
2 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Function Known Explain 0.58659
3 Language Delay Disease Known Explain 0.56535
4 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Function Known Explain 0.54003
5 Bannayan-Riley-Ruvalcaba Syndrome Other Known Explain 0.49336
6 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Function Known Explain 0.41803
7 phosphatidylethanolamine Compound Known Explain 0.37985
8 inositol-1,3,-bisphosphate 3-phosphatase activity Function Known Explain 0.36404
9 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN Domain Known Explain 0.35431
10 Cutaneous Melanoma Disease Known Explain 0.31812
11 Lipoma Disease Known Explain 0.31553
12 Developmental Coordination Disorder Disease Known Explain 0.29025
13 MENINGIOMA, FAMILIAL Disease Known Explain 0.27966
14 regulation of B cell apoptosis Function Known Explain 0.25660
15 Lipomatosis Disease Known Explain 0.25508
16 Phosphatidylserines Compound Known Explain 0.24132
17 miRBase:hsa-mir-217 MicroRNA Known Explain 0.23861
18 Phosphatidylinositol-3,4,5-trisphosphate Compound Known Explain 0.23079
19 phosphoinositide dephosphorylation Function Known Explain 0.21409
20 VACTERL ASSOCIATION WITH HYDROCEPHALUS Disease Known Explain 0.21088
21 inositol phosphate dephosphorylation Function Known Explain 0.20438
22 Phosphatase tensin type Domain Known Explain 0.20040
23 negative regulation of phagocytosis Function Known Explain 0.19425
24 Endometrial Hyperplasia Disease Known Explain 0.19418
25 Tensin phosphatase, C2 domain Domain Known Explain 0.18852
26 regulation of myeloid cell apoptosis Function Known Explain 0.18296
27 negative regulation of focal adhesion formation Function Known Explain 0.16411
28 LEOPARD Syndrome Disease Known Explain 0.16033
29 Proteus Syndrome Disease Known Explain 0.15270
30 Follicular thyroid carcinoma Disease Known Explain 0.14925
31 Hamartoma Syndrome, Multiple Disease Known Explain 0.14799
32 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate Compound Known Explain 0.14674
33 Hemangioma Disease Known Explain 0.13276
34 negative regulation of protein kinase B signaling cascade Function Known Explain 0.13256
35 Phosphatidylcholines Compound Known Explain 0.11626
36 lipid phosphatase activity Function Inferred Explain 0.11215
37 Hypertrophy Disease Known Explain 0.10969
38 response to arsenic Function Known Explain 0.10376
39 cardiac muscle development Function Known Explain 0.10073
40 platelet-derived growth factor receptor binding Function Known Explain 0.09870
41 Dual specificity phosphatase, catalytic domain Domain Known Explain 0.09801
42 miRBase:hsa-mir-19a MicroRNA Known Explain 0.09273
43 regulation of protein stability Function Known Explain 0.08203
44 endothelial cell migration Function Known Explain 0.08112
45 response to ATP Function Known Explain 0.07782
46 platelet-derived growth factor receptor signaling pathway Function Known Explain 0.06690
47 Pseudopapilledema Disease Inferred Explain 0.06573
48 response to zinc ion Function Known Explain 0.06452
49 Polydactyly Other Known Explain 0.06230
50 Developmental Disabilities Disease Known Explain 0.05713
51 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate Compound Known Explain 0.04896
52 miRBase:hsa-mir-26a MicroRNA Known Explain 0.04761
53 MAST3 gene Gene Known Explain 0.04483
54 protein tyrosine/serine/threonine phosphatase activity Function Known Explain 0.04400
55 miRBase:hsa-mir-214 MicroRNA Known Explain 0.04378
56 MVP gene Gene Known Explain 0.04351
57 CHGB gene Gene Known Explain 0.04310
58 negative regulation of protein amino acid phosphorylation Function Known Explain 0.04241
59 MAGI2 gene Gene Known Explain 0.04099
60 Endometrial Neoplasms Disease Known Explain 0.04035
61 MAST1 gene Gene Known Explain 0.03918
62 FRK gene Gene Known Explain 0.03905
63 negative regulation of epithelial cell proliferation Function Known Explain 0.03784
64 MAGI3 gene Gene Known Explain 0.03734
65 HBA1 gene Gene Known Explain 0.03714
66 Memory Function Known Explain 0.03615
67 Multiple congenital anomalies Other Known Explain 0.03482
68 Head and Neck Neoplasms Disease Known Explain 0.03465
69 SQUAMOUS CELL CARCINOMA, HEAD AND NECK Disease Known Explain 0.03457
70 Protein-tyrosine phosphatase, active site Domain Known Explain 0.03370
71 Macrocephaly Other Inferred Explain 0.03327
72 Profound Mental Retardation Disease Known Explain 0.03322
73 negative regulation of cell migration Function Known Explain 0.03254
74 MAST2 gene Gene Known Explain 0.03217
75 protein serine/threonine phosphatase activity Function Known Explain 0.03151
76 protein stabilization Function Known Explain 0.03145
77 positive regulation of transcription factor activity Function Known Explain 0.03084
78 regulation of cyclin-dependent protein kinase activity Function Known Explain 0.02995
79 UTP14A gene Gene Known Explain 0.02825
80 PDZ domain binding Function Known Explain 0.02816
81 Sirolimus Compound Known Explain 0.02605
82 Inositol Phosphate Metabolism Pathway Function Known Explain 0.02402
83 Meningioma, benign, no ICD-O subtype Disease Inferred Explain 0.02374
84 Wnt receptor signaling pathway through beta-catenin Function Known Explain 0.02374
85 leukemia Disease Known Explain 0.02348
86 Refractive Errors Disease Inferred Explain 0.02320
87 SLC9A3R2 gene Gene Known Explain 0.02295
88 Glioma Disease Known Explain 0.02244
89 Endometrial cancer - Homo sapiens (human) Pathway Known Explain 0.02161
90 response to glucose stimulus Function Known Explain 0.02159
91 ANG gene Gene Known Explain 0.02153
92 inositol or phosphatidylinositol phosphatase activity Function Inferred Explain 0.02143
93 protein tyrosine phosphatase activity Function Known Explain 0.02079
94 miRBase:hsa-mir-21 MicroRNA Known Explain 0.02075
95 STK11 gene Gene Known Explain 0.01933
96 response to estradiol stimulus Function Known Explain 0.01929
97 Dysplastic Nevus Syndrome Disease Inferred Explain 0.01907
98 C2 calcium/lipid-binding region, CaLB Domain Known Explain 0.01895
99 Glioma - Homo sapiens (human) Pathway Known Explain 0.01886
100 SLC9A3R1 gene Gene Known Explain 0.01866