extracellular region

Component • C0521119

Definition

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular pa

Synonyms

extracellular region • extracellular

Linked items?Related concepts, ordered by their global importance in the network.

TNF gene    cellular_component    EGFR gene    IL6 gene    IL8 gene    IL1B gene    TGFB1 gene    ALB gene    APP gene    VEGFA gene    CCL2 gene    CALM1 gene    IFNG gene    FAS gene    TNFRSF1A gene    IL10 gene    SFN gene    FGFR2 gene    BMP4 gene    MMP9 gene   

Related concepts

# Concept name Type Relation Support Score
1 hormone activity Function Inferred Explain 0.03306
2 Pathogenesis Disease Inferred Explain 0.02946
3 defense response to bacterium Function Inferred Explain 0.02712
4 Extracellular Space Other Inferred Explain 0.02106
5 peptidase inhibitor activity Function Inferred Explain 0.01547
6 proteinaceous extracellular matrix Component Inferred Explain 0.01281
7 serine-type endopeptidase inhibitor activity Function Inferred Explain 0.00908
8 Proteolysis Function Inferred Explain 0.00713
9 cytokine activity Function Inferred Explain 0.00624
10 peptidase activity Function Inferred Explain 0.00613
11 Immune response Function Inferred Explain 0.00566
12 serine-type endopeptidase activity Function Inferred Explain 0.00562
13 sodium channel inhibitor activity Function Inferred Explain 0.00494
14 growth factor activity Function Inferred Explain 0.00482
15 IPR012351 Domain Inferred Explain 0.00479
16 Aerolysin/haemolysin toxin, conserved site Domain Known Explain 0.00471
17 neuropeptide hormone activity Function Inferred Explain 0.00471
18 IPR021116 Domain Known Explain 0.00415
19 B melanoma antigen Domain Inferred Explain 0.00403
20 Cyclosporine Compound Inferred Explain 0.00400
21 IPR021117 Domain Known Explain 0.00399
22 Calcitonin, conserved site Domain Known Explain 0.00394
23 Natriuretic peptide Domain Known Explain 0.00393
24 Calcitonin-like Domain Known Explain 0.00389
25 Snake toxin binding site Domain Known Explain 0.00367
26 Protein Binding Function Inferred Explain 0.00365
27 Tetrachlorodibenzodioxin Compound Inferred Explain 0.00361
28 Cell membrane Component Inferred Explain 0.00361
29 Four-helical cytokine-like, core Domain Inferred Explain 0.00356
30 Crustacean neurohormone, conserved site Domain Known Explain 0.00353
31 Benzo(a)pyrene Compound Inferred Explain 0.00350
32 Cell Adhesion Function Inferred Explain 0.00341
33 hemolysis by symbiont of host erythrocytes Function Inferred Explain 0.00338
34 calcium ion binding Function Inferred Explain 0.00333
35 Crustacean neurohormone Domain Known Explain 0.00333
36 Snake cytotoxin Domain Known Explain 0.00324
37 Enterotoxin, bacterial Domain Inferred Explain 0.00320
38 Cytokine-cytokine receptor interaction - Homo sapiens (human) Pathway Inferred Explain 0.00316
39 Estradiol Compound Inferred Explain 0.00316
40 Receptor Binding Function Inferred Explain 0.00311
41 Aerolysin cytolytic toxin Domain Known Explain 0.00304
42 Snake toxin Domain Known Explain 0.00296
43 Parathyroid hormone Domain Known Explain 0.00291
44 Binding (Molecular Function) Function Inferred Explain 0.00290
45 Signal Transduction Function Inferred Explain 0.00282
46 Secreted growth factor Wnt protein Domain Known Explain 0.00278
47 multicellular organismal development Function Inferred Explain 0.00273
48 Whey acidic protein, 4-disulphide core Domain Known Explain 0.00273
49 Leukocidin/haemolysin Domain Known Explain 0.00273
50 Gonadotropin, beta subunit Domain Known Explain 0.00271
51 Allergen V5/Tpx-1 related, conserved site Domain Known Explain 0.00264
52 Insulin-like growth factor-binding protein, IGFBP Domain Known Explain 0.00260
53 metalloendopeptidase activity Function Inferred Explain 0.00258
54 Allergen V5/Tpx-1 related Domain Known Explain 0.00254
55 Extracellular Matrix Other Inferred Explain 0.00252
56 defense response Function Inferred Explain 0.00250
57 Bi-component toxin, staphylococci Domain Known Explain 0.00246
58 Innate Immune Response Disease Inferred Explain 0.00246
59 molecular_function Function Inferred Explain 0.00244
60 negative regulation of endopeptidase activity Function Inferred Explain 0.00243
61 Crustacean neurohormone CHH Domain Known Explain 0.00242
62 Crustacean neurohormone MIH/MOIH/GIH Domain Known Explain 0.00242
63 Heparin Binding Function Inferred Explain 0.00240
64 Inflammatory Response Disease Inferred Explain 0.00239
65 EGF-like, type 3 Domain Inferred Explain 0.00237
66 Toxin, beta-grasp, Staphylococcal/Streptococcal Domain Known Explain 0.00236
67 EGF-like Domain Inferred Explain 0.00235
68 GPHA2 gene Gene Known Explain 0.00234
69 EGF-like region, conserved site Domain Inferred Explain 0.00233
70 Aerolysin/haemolysin/leukocidin toxin Domain Known Explain 0.00233
71 Gonadotropin, beta subunit, conserved site Domain Known Explain 0.00233
72 Islet amyloid polypeptide Domain Known Explain 0.00232
73 Corticotropin-releasing factor, CRF Domain Known Explain 0.00231
74 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site Domain Known Explain 0.00230
75 extracellular matrix structural constituent Function Inferred Explain 0.00229
76 Peptidase S1A, chymotrypsin Domain Inferred Explain 0.00229
77 integral to membrane Component Inferred Explain 0.00225
78 Membrane Component Inferred Explain 0.00223
79 Insulin-like Domain Known Explain 0.00222
80 IPR015476 Domain Known Explain 0.00221
81 Leukocidin/porin Domain Known Explain 0.00220
82 Conotoxin Domain Known Explain 0.00220
83 IPR021118 Domain Known Explain 0.00219
84 CALCB gene Gene Known Explain 0.00219
85 Bordetella pertussis toxin B Domain Known Explain 0.00218
86 Aflatoxin B1 Compound Inferred Explain 0.00218
87 pancreatic ribonuclease activity Function Inferred Explain 0.00213
88 Galanin Domain Known Explain 0.00213
89 IPR022321 Domain Known Explain 0.00211
90 Aerolysin/Pertussis toxin APT Domain Known Explain 0.00210
91 Cytoplasm Component Inferred Explain 0.00210
92 arsenic trioxide Compound Inferred Explain 0.00210
93 ion channel inhibitor activity Function Inferred Explain 0.00210
94 PI15 gene Gene Known Explain 0.00208
95 IAPP gene Gene Known Explain 0.00207
96 Adipokinetic hormone 2 Domain Known Explain 0.00205
97 PI16 gene Gene Known Explain 0.00205
98 Intercellular Communication Function Inferred Explain 0.00204
99 chemokine activity Function Inferred Explain 0.00203
100 Mating factor alpha Domain Known Explain 0.00203