TP53 gene

Gene • C0079419

Definition

This gene plays a critical role in cell cycle regulation and has tumor suppressor activity.

Synonyms

TP53 gene • Gene, TP53 • Genes, TP53 • TP53 Genes • Genes, p53 • Gene, p53 • p53 Gene • p53 Genes • Li-Fraumeni syndrome • P53 • TP53 • TUMOR PROTEIN p53 • TRP53 • Tumor Protein P53 (Li-Fraumeni Syndrome) Gene • TRANSFORMATION-RELATED PROTEIN 53 • LFS1 • GENES P 053 • TP A 053 GENES • GENES TP 053 • P A 053 GENES

Linked items?Related concepts, ordered by their global importance in the network.

Cell Nucleus    Protein Binding    Cytoplasm    Cyclosporine    Metal Ion Binding    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    Benzo(a)pyrene    DNA Binding    Tetrachlorodibenzodioxin    zinc ion binding    ATP binding    Cytoplasmic matrix    Estradiol    arsenic trioxide    Aflatoxin B1    Calcium Valproate    Selenium    Vitamin E    regulation of transcription, DNA-dependent    Mitochondria   

Related concepts

# Concept name Type Relation Support Score
1 CDKN1A gene Gene Known Explain 0.01985
2 BAX gene Gene Inferred Explain 0.00689
3 BCL2 gene Gene Known Explain 0.00677
4 CASP3 gene Gene Inferred Explain 0.00593
5 Quinacrine Compound Known Explain 0.00551
6 ADRENOCORTICAL CARCINOMA, HEREDITARY Disease Known Explain 0.00524
7 Cell Nucleus Component Known Explain 0.00522
8 RV 538 Compound Known Explain 0.00512
9 Zeocin Compound Known Explain 0.00512
10 1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol Compound Known Explain 0.00512
11 MDM2 gene Gene Known Explain 0.00508
12 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one Compound Known Explain 0.00501
13 cis-bis(3-aminoflavone)dichloroplatinum(II) Compound Known Explain 0.00499
14 Protein Binding Function Known Explain 0.00499
15 LI-FRAUMENI SYNDROME 1 Disease Known Explain 0.00499
16 S-ethyl glutathione Compound Known Explain 0.00496
17 selenium oxide Compound Known Explain 0.00496
18 bathocuproine Compound Known Explain 0.00493
19 8-azapurine Compound Known Explain 0.00488
20 AG 337 Compound Known Explain 0.00486
21 phenylhydroquinone Compound Known Explain 0.00485
22 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine Compound Known Explain 0.00485
23 Aminacrine Compound Known Explain 0.00485
24 tryptanthrine Compound Known Explain 0.00481
25 BML 210 Compound Known Explain 0.00478
26 dimefox Compound Known Explain 0.00477
27 Phenindione Compound Known Explain 0.00477
28 AN-7 phosphate cpd Compound Known Explain 0.00476
29 11,11'-dideoxyverticilin Compound Known Explain 0.00473
30 3,4,5,4'-tetramethoxystilbene Compound Known Explain 0.00466
31 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide Compound Known Explain 0.00466
32 2-butylamino-2-demethoxy-hypocrellin B Compound Known Explain 0.00466
33 TDP 665759 Compound Known Explain 0.00463
34 MAGEA2 gene Gene Known Explain 0.00461
35 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one Compound Known Explain 0.00460
36 2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone Compound Known Explain 0.00456
37 TP73 gene Gene Known Explain 0.00455
38 3-aminothioacridone Compound Known Explain 0.00452
39 tempol Compound Known Explain 0.00451
40 O-(chloroacetylcarbamoyl)fumagillol Compound Known Explain 0.00449
41 7-monohydroxyethylrutoside Compound Known Explain 0.00447
42 bisindolylmaleimide IX Compound Known Explain 0.00445
43 tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex Compound Known Explain 0.00441
44 NSC 707545 Compound Known Explain 0.00439
45 S-Nitroso-N-Acetylpenicillamine Compound Known Explain 0.00438
46 CGP 41251 Compound Known Explain 0.00432
47 eleostearic acid Compound Known Explain 0.00431
48 spermine nitric oxide complex Compound Known Explain 0.00431
49 procyanidin Compound Known Explain 0.00425
50 CHEK2 gene Gene Known Explain 0.00425
51 KIAA0087 gene Gene Known Explain 0.00423
52 S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea Compound Known Explain 0.00421
53 2'-cyano-2'-deoxyarabinofuranosylcytosine Compound Known Explain 0.00415
54 sodium-(2-(4-(7-chloro-2-quinoxalinyloxy)phenoxy)propionate) Compound Known Explain 0.00414
55 9,11-linoleic acid Compound Known Explain 0.00412
56 Acridine Orange Compound Known Explain 0.00403
57 S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea Compound Known Explain 0.00400
58 CABLES2 gene Gene Known Explain 0.00400
59 N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine Compound Known Explain 0.00400
60 Sodium Benzoate Compound Known Explain 0.00398
61 allose Compound Known Explain 0.00391
62 tripchlorolide Compound Known Explain 0.00390
63 CASP9 gene Gene Inferred Explain 0.00390
64 benzo(a)pyrene diolepoxide I Compound Known Explain 0.00389
65 PFL protocol Other Known Explain 0.00386
66 alliin Compound Known Explain 0.00380
67 cellular response to glucose starvation Function Known Explain 0.00379
68 diallyl disulfide Compound Known Explain 0.00379
69 MAGEB18 gene Gene Known Explain 0.00378
70 2-phenylphenol Compound Known Explain 0.00377
71 Nitrogen Mustard Compounds Compound Known Explain 0.00375
72 PARP1 gene Gene Known Explain 0.00374
73 Nimustine Compound Known Explain 0.00373
74 IC 261 Compound Known Explain 0.00373
75 Pirarubicin Compound Known Explain 0.00371
76 TDP 521252 Compound Known Explain 0.00370
77 THAP8 gene Gene Known Explain 0.00370
78 Mustard Compounds Compound Known Explain 0.00370
79 RB1 gene Gene Inferred Explain 0.00369
80 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid Compound Known Explain 0.00369
81 DNA strand renaturation Function Known Explain 0.00369
82 DNA strand annealing activity Function Known Explain 0.00367
83 DNA damage response, signal transduction by p53 class mediator Function Known Explain 0.00362
84 S-(1,2-dichlorovinyl)cysteine Compound Known Explain 0.00361
85 Li-Fraumeni Syndrome Disease Known Explain 0.00361
86 Choroid Plexus Papilloma Disease Known Explain 0.00361
87 matrine Compound Known Explain 0.00360
88 O(6)-benzylguanine Compound Known Explain 0.00358
89 ZD 9331 Compound Known Explain 0.00358
90 N-hydroxy-4-aminobiphenyl Compound Known Explain 0.00355
91 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine Compound Known Explain 0.00354
92 CA11 gene Gene Known Explain 0.00350
93 PPP1R13L gene Gene Known Explain 0.00348
94 ZNF420 gene Gene Known Explain 0.00347
95 7-hydroxystaurosporine Compound Known Explain 0.00344
96 4-oxofenretinide Compound Known Explain 0.00343
97 mithramycin A Compound Known Explain 0.00342
98 SB 216763 Compound Known Explain 0.00342
99 Cytoplasm Component Known Explain 0.00342
100 Asbestos, Amosite Compound Known Explain 0.00341