Amsacrine

Compound • C0002699

Definition

An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase

Synonyms

Amsacrine • AMSA • Cains Acridine • m-AMSA • AMSA M • meta-AMSA • meta AMSA • Methanesulfonamide, N-(4-(9-acridinylamino)-3-methoxyphenyl)- • N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide • acridinyl anisidide • Cain's Acridine • Cain Acridine • Cain''s Acridine • Acridine, Cain's • 4'-(9-Acridinylamino)methane-sulfon-m-anisidide • Amsacrine [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

TP53 gene    MYC gene    BCL2 gene    BAX gene    ALB gene    MDM2 gene    CCNB1 gene    CCNE1 gene    Leukemia, Myelocytic, Acute    TOP2A gene    CCNA2 gene    EGF gene    KCNH2 gene    NCL gene    RAD51 gene    RARB gene    WRN gene    CASP2 gene    UBE2C gene    TOP2B gene   

Related concepts

# Concept name Type Relation Support Score
1 Aminoacridines Compound Known Explain 4.28191
2 Herpes Simplex Infections Disease Known Explain 1.57587
3 PRC1 gene Gene Known Explain 1.51085
4 TP53I3 gene Gene Known Explain 1.32405
5 UBE2C gene Gene Known Explain 0.88817
6 TOP2B gene Gene Known Explain 0.86229
7 CASP2 gene Gene Known Explain 0.84615
8 NCL gene Gene Known Explain 0.73790
9 RARB gene Gene Known Explain 0.67027
10 WRN gene Gene Known Explain 0.66356
11 RAD51 gene Gene Known Explain 0.66016
12 CCNA2 gene Gene Known Explain 0.50530
13 EGF gene Gene Known Explain 0.49013
14 TOP2A gene Gene Known Explain 0.44983
15 KCNH2 gene Gene Known Explain 0.40809
16 CCNE1 gene Gene Known Explain 0.40710
17 CCNB1 gene Gene Known Explain 0.38074
18 Leukemia, Myelocytic, Acute Disease Known Explain 0.36125
19 MDM2 gene Gene Known Explain 0.26399
20 BAX gene Gene Known Explain 0.25713
21 ALB gene Gene Known Explain 0.18794
22 MYC gene Gene Known Explain 0.13603
23 BCL2 gene Gene Known Explain 0.12979
24 TP53 gene Gene Known Explain 0.12420
25 Quinacrine Compound Inferred Explain 0.08379
26 Aminacrine Compound Inferred Explain 0.07706
27 Acridine Orange Compound Inferred Explain 0.06188
28 Acridines Compound Inferred Explain 0.05383
29 Tacrine Compound Inferred Explain 0.04999
30 Quinacrine Mustard Compound Inferred Explain 0.01011
31 Centella asiatica extract Compound Inferred Explain 0.00700
32 Herpes Labialis Disease Inferred Explain 0.00650
33 Stomatitis, Herpetic Disease Inferred Explain 0.00634
34 Acyclovir Compound Inferred Explain 0.00611
35 Keratitis, Herpetic Disease Inferred Explain 0.00582
36 Fluanxol Compound Inferred Explain 0.00563
37 phosphomannopentaose sulfate Compound Inferred Explain 0.00559
38 plant extract, Houttuynia cordata Compound Inferred Explain 0.00482
39 genital herpes Disease Inferred Explain 0.00444
40 Chlorprothixene Compound Inferred Explain 0.00404
41 Etoposide Compound Inferred Explain 0.00401
42 Protein Binding Function Inferred Explain 0.00379
43 Mangifera indica extract Compound Inferred Explain 0.00353
44 Cell Nucleus Component Inferred Explain 0.00351
45 Camptothecin Compound Inferred Explain 0.00332
46 Skin Diseases, Viral Disease Inferred Explain 0.00331
47 CASP3 gene Gene Inferred Explain 0.00304
48 hydroxyurea Compound Inferred Explain 0.00283
49 Cytoplasm Component Inferred Explain 0.00271
50 Doxorubicin Compound Inferred Explain 0.00248
51 CDKN1A gene Gene Inferred Explain 0.00242
52 Cyclosporine Compound Inferred Explain 0.00235
53 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Inferred Explain 0.00232
54 Herpesviridae Infections Disease Inferred Explain 0.00230
55 Estradiol Compound Inferred Explain 0.00226
56 Chlorpromazine Compound Inferred Explain 0.00206
57 Nitrogen Mustard Compounds Compound Inferred Explain 0.00203
58 resveratrol Compound Inferred Explain 0.00200
59 mangiferin Compound Inferred Explain 0.00200
60 arsenic trioxide Compound Inferred Explain 0.00190
61 Fluorouracil Compound Inferred Explain 0.00187
62 PARP1 gene Gene Inferred Explain 0.00187
63 Stomatitis Disease Inferred Explain 0.00186
64 Benzo(a)pyrene Compound Inferred Explain 0.00184
65 Lip Diseases Disease Inferred Explain 0.00182
66 Nucleoplasm Component Inferred Explain 0.00181
67 bicalutamide Compound Inferred Explain 0.00175
68 Tretinoin Compound Inferred Explain 0.00166
69 Tetrachlorodibenzodioxin Compound Inferred Explain 0.00161
70 CDK2 gene Gene Inferred Explain 0.00160
71 CASP9 gene Gene Inferred Explain 0.00160
72 Acridones Compound Inferred Explain 0.00157
73 RB1 gene Gene Inferred Explain 0.00156
74 Plant Extracts Compound Inferred Explain 0.00152
75 PVRL1 gene Gene Inferred Explain 0.00147
76 Cytoplasmic matrix Component Inferred Explain 0.00144
77 Mitotic Recombination Function Inferred Explain 0.00142
78 Daunorubicin Compound Inferred Explain 0.00139
79 sodium arsenite Compound Inferred Explain 0.00137
80 DNA Binding Function Inferred Explain 0.00135
81 Vincristine Compound Inferred Explain 0.00133
82 Genistein Compound Inferred Explain 0.00133
83 BCL2L1 gene Gene Inferred Explain 0.00131
84 nucleotide binding Function Inferred Explain 0.00131
85 CASP8 gene Gene Inferred Explain 0.00128
86 TDP 521252 Compound Inferred Explain 0.00127
87 Malignant neoplasm of breast Disease Inferred Explain 0.00127
88 decitabine Compound Inferred Explain 0.00127
89 ESR1 gene Gene Inferred Explain 0.00127
90 Aflatoxin B1 Compound Inferred Explain 0.00125
91 ellipticine Compound Inferred Explain 0.00125
92 mitotic spindle elongation Function Inferred Explain 0.00122
93 melanoma Disease Inferred Explain 0.00122
94 Eye Infections, Viral Disease Inferred Explain 0.00121
95 ATP binding Function Inferred Explain 0.00120
96 myricetin Compound Inferred Explain 0.00120
97 CDK1 gene Gene Inferred Explain 0.00119
98 CCND1 gene Gene Inferred Explain 0.00118
99 tert-Butylhydroperoxide Compound Inferred Explain 0.00118
100 Neuroblastoma Disease Inferred Explain 0.00117